Characterization of Genome-Wide DNA Methylation and Hydroxymethylation in Mouse Arcuate Nucleus of Hypothalamus During Puberty Process
Background: Pulsatile pituitary gonadotropin secretion governed by hypothalamic gonadotropin-releasing hormone (GnRH) is essential for the pubertal onset.The epigenetic mechanism underlying the activation of GnRH-dependent regulatory axis in hypothalamus remains elusive.This study aims to explore the potential correlation between the signature of D