CHARACTERIZATION OF GENOME-WIDE DNA METHYLATION AND HYDROXYMETHYLATION IN MOUSE ARCUATE NUCLEUS OF HYPOTHALAMUS DURING PUBERTY PROCESS

Characterization of Genome-Wide DNA Methylation and Hydroxymethylation in Mouse Arcuate Nucleus of Hypothalamus During Puberty Process

Background: Pulsatile pituitary gonadotropin secretion governed by hypothalamic gonadotropin-releasing hormone (GnRH) is essential for the pubertal onset.The epigenetic mechanism underlying the activation of GnRH-dependent regulatory axis in hypothalamus remains elusive.This study aims to explore the potential correlation between the signature of D

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Differential enrichment of H3K9me3 at annotated satellite DNA repeats in human cell lines and during fetal development in mouse

Abstract Background Trimethylation of histone H3 on lysine 9 (H3K9me3) at satellite DNA sequences has been primarily studied at (peri)centromeric regions, where its level shows Weight Control differences associated with various processes such as development and malignant transformation.However, the dynamics of H3K9me3 at distal satellite DNA repeat

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